Objectives To assess the efficacy of Chymotrypsin‐trypsin with Diclofenac versus Diclofenac alone on the postoperative sequelae of lower third molar disimpactions. Methods A total of 60 patients to undergo lower third molar surgery were divided randomly into 2 equal groups. Group 1 (30 patients) received Chymotrypsin‐trypsin with Diclofenac tablets and conventional treatment whilst Group 2 (30 patients) received Diclofenac Potassium 50 mg and conventional treatment. Pain, facial swelling, and Interincisal opening were measured for each patient on the 1st, 3rd and 7th days postoperatively. Results In GROUP 1, the mean reduction of VAS Score for postoperative pain was 4.33 to 0.76, whereas GROUP 2 reported a decrease in score from 3.06 to 0.93. During the time period of Day 1 to Day 7, GROUP 1 reported a mean reduction of swelling score to 0.26 on Day 7, whilst GROUP 2 reported a swelling score of 0.80 on Day 7. For the Interincisal Opening and Trismus, GROUP 1 had mean scores from 0.40 (Day 1) to 1.10 (Day 3) and 0.26 on Day 7, whilst GROUP 2 had mean scores from 0.63 (Day 1) to 1.20 (day 3) and 0.73 at Day 7. GROUP 1 reported no Adverse symptoms, whereas GROUP 2 showed symptoms on Day 1 and Day 3. Conclusion Trypsin‐Chymotrypsin in combination with Diclofenac is an effective and superior analgesic when compared to Diclofenac alone in the treatment of postoperative sequelae of lower third molar surgery with good anti‐inflammatory activity.

Objectives: Trans-alveolar extractions involve surgical removal of tooth that has its own postoperative sequelae, most commonly manifested as pain and swelling. This study aims to compare the efficacy of topical ozone and dexamethasone in management of post-operative sequelae after mandibular trans-alveolar molar extractions. Materials and Methods: Sixty patients requiring surgical removal of mandibular molars under local anesthesia were randomly allocated into two groups, each group consisting of 30 patients. Group 1 received Topical Ozonated Oil in the extraction socket post-operatively, while Group 2 was administered 8 mg dexamethasone injection post-operatively. The patients were checked for postoperative wound healing, pain and swelling on 1st, 3rd and 7th day. Results: The results showed comparatively similar results for the pain severity and swelling score at the 1st and 7th postoperative day in both the groups. A greater reduction of pain was noticed in Group 1 on 3rd postoperative day. Wound Healing was noted to be better in Group 1 at 3rd and 7th post-operative day. Conclusion: In conclusion, topical ozone therapy can be used as an effective alternative treatment modality, when compared to dexamethasone for better management of post-operative sequelae following mandibular trans-alveolar molar extractions.