We have come across an unexpected domino dipolar cycloaddition-ring opening reaction between electrophilic indoles and isoquinolinium methylides for accessing functionalized pyrrolo[2,1-a]isoquinolines. The reaction was found to be general yielding the...

The present review describes the methods reported for the synthesis of 3(2H)-furanones. This heterocycle forms the core structure of a number of natural products and biologically active scaffolds. We have covered all reports available on the synthesis of 3(2H)-furanone derivatives and have divided the review into several sections based on the substitution patterns

An efficacious, metal-free strategy has been developed for the synthesis of 4-aryl-3-(2H)-furanones. The reaction proceeds via the nucleophilic addition of an active methylene compound to the aryne followed by ring closing of the adduct. The reaction proceeds under mild conditions, is applicable for gram-scale synthesis of 4-aryl-3-(2H)-furanones, and is general for a range of substituted arynes and haloacetates.