Cold recycling technologies such as full-depth reclamation (FDR) are sustainable and cost-effective techniques for pavement rehabilitation that reduce environmental impacts and construction costs and time. The limited information available on the material properties of FDR mixtures and their characterization in mechanistic-empirical (M-E) pavement design hinders the full deployment of FDR. Previous research has found current M-E default values to be non-representative and overly conservative, leading to an underestimation of the true performance capabilities of FDR materials. To address this gap, this paper analyzes the performance of 11 FDR sites constructed throughout Colorado, U.S., and compares their long-term performance with M-E predictions. The objective of this paper is to recommend input values for the M-E design of FDR base materials that result in reliable predictions of FDR long-term performance. The analysis includes both non-stabilized and emulsion-stabilized FDR projects. Both initial International Roughness Index (IRI) and resilient modulus were found to have a significant impact on M-E predictions and were calibrated in a two-step process. The proposed input parameters lead to a conservative design of FDR projects and result in improved IRI predictions compared with the ones derived from current design criteria. With the current design parameters, IRI predictions were, on average, overestimated by 51 in./mi, whereas the proposed input parameters make it possible to reduce this difference to 17 in./mi. Future research is needed to improve current models in M-E pavement design software to adequately model cold in-place recycled layers such as FDR.