No abstract

therefore biochemistry laboratories throughout UK receive a substantial number of requests for coeliac serological assessments every year. Objective We set out to review the total number of requested anti-endomysial antibody (AEAs) and anti-tissue transglutaminase (ATTG) tests between 2007 and 2013 at a busy district general hospital, and reviewed the outcome of having made that request.Methods The results of all the coeliac serology requests made during the study period were reviewed and a retrospective analysis was made of the hospital records to find out the outcome in all those patients with positive results. The laboratory issued a positive result if the ATTG was greater or equal to 4. Results During 2007, 810 AEAs were requested, of which 30 (3.7%) were positive (10 were weak positive), 736 were negative, 44 were not done. In 2008 ATTG became the primary coeliac serology test and AEAs were only used to review gluten free dietary (GFD) compliance. Between Jan 2008 and Dec 2013 a total of 20,677 ATTGs were requested. This has steadily increase year on year. In 2008 there were 913 requests, 1,389 in 2009, 3,060 in 2010, 4,238 in 2011, 5,584 in 2012 and 6,483 in 2013. Of these 785 (3.6%) proved positive, 19891 were negative, 372 samples were deemed insufficient and 605 were rejected by the laboratory as not indicated. Histological confirmation of coeliac disease was made in 222 patients, however a large proportion of positive serology received no further assessment. Conclusion There is an ever increasing number of requests for coeliac serology, costing our local CCG £21,070 in 2013. Despite the positive pick up rate being high at 3.6%, a large number of positive results were not pursued any further, with patients failing to have a definitive diagnosis made. It is important to ensure that there are robust mechanisms of chasing up on hospital results, and acting on them appropriately to prevent delayed or missed diagnoses. Disclosure of Interest None Declared. PTU-161 ENDOSCOPIC BOUGIE DILATATION IS EFFECTIVE AND SAFE FOR OES OPHAGEAL AND PHARYNGEAL STRICTURES: OUTCOMES OF A LARGE CASE SERIESMR Smith*, B Drinkwater, M Widlak, NC Fisher. Gastroenterology, Dudley Group Hospitals NHS Foundation Trust, Dudley, UK 10. 1136/gutjnl-2014-307263.235 Introduction Endoscopic bougie dilatation is a traditional technique for managing oesophageal strictures. There are some safety concerns with this technique, but no corroborative evidence of this in controlled or uncontrolled studies to date. Methods We evaluated the outcomes and safety of endoscopic bougie dilatation at our centre, using the endoscopy database to identify all dilatations done by a single operator. Bougies were the preferred option for all dilatations. All cases from January 2007 to March 2013 were then reviewed by case note analysis. Results 146 patients were identified, who underwent a total of 346 bougie dilatations. Median age was 67 yrs (range 27-91). Indications for dilatation were: peptic stricture 80 (55%), malignant stricture 20 (14%), post-surg...