No abstract

A convenient method of accessing imidazole 2-halo derivatives is proposed, comprising O-acylation of imidazole N-oxide fluoroborate complexes with tosyl halogenides which further undergo cine-substitution of 3-tosyl group with a halogen anion. In conjunction with a previously proposed method of synthesizing N-oxides of 2-unsubstituted 1-arylimidazoles this method enables one to substantially expand the range of accessible compounds.

Considerable attention holds on the chemistry and application of heterocyclic N-oxides due to their advantages as building-blocks in organic synthesis and importance in biomedical research. On the other hand, in recent years the development of selective methods for constructing C