Obviously, the only optimal approach to patients with rheumatoid arthritis is individual and multidisciplinary, in order to consider interactions between their pain, their inflammation, patient's mental functions and their motor abilities.

The aim of this study was to estimate the genetic parameters and breeding values for reproduction traits of Landrace sows in the first three parities by Animal model. Records of 2238 first parity; 2125 second parity and 1872 third parity Landrace sows farrowing between 2007 and 2012 were included in the analysis. The traits included in the analyses were total pigs born (TB), number of pigs born alive (NBA), number of pigs weaned (NW) and litter weaning weight (LW) in the parities. The genetic parameters were estimated using a multivariate analyses Animal model using REML procedure. Estimates of heritability for TB were 0.03, 0.05 and 0.18, for NBA were 0.04, 0.02 and 0.17, for NW were 0.08, 0.08 and 0.01 and for LW were 0.09, 0.11 and 0.03 for parities 1 to 3. Genetic and phenotypic variance were increased from the first to the third parity. Between the majorities of studied reproductive traits were the recorded positive genetic and phenotypic correlations, except between LW and other analyzed properties where they recorded a high correlation negative in third parity. Means of estimated breeding values of reproductive traits from first parity to third parity was indecreased.

SUMMARY 1. Thyroid activity was studied with 131I injected intraperitoneally. The uptake of 131I was followed in the living animal. The animals were brought into a state of hypoxic hypothermia by Giaja's method [1940]. 2. The thyroid gland is completely inactive at body temperatures of between 15 and 20° C. 3. At body temperatures of between 23 and 28° C, thyroid activity is decreased, but is large enough, over a sufficiently long period of time, to concentrate normal quantities of iodine. 4. Thyroid activity is unchanged when a normal body temperature is regained after a single or four to six successive phases of hypothermia.

SUMMARY Hibernation in the ground squirrel ends within 1–2 hr after total adrenalectomy and does not recur. Survival time after adrenalectomy in laboratory-kept ground squirrels during November and December was longer than it was during September-October and February-March. Body temperature during hibernation (4–18° C) was restored to normal (37° C) within 1–2 hr after adrenalectomy, the animals being kept in a room at 17° C. Oxygen consumption was measured in ground squirrels on the 6th and 7th days after adrenalectomy at 31–32° and 4° C respectively. Maximum consumption occurred at 4° C; normal body temperature was retained. The 131I uptake by the thyroid of non-hibernating ground squirrels is considerably smaller in early Autumn (September-October) than during the winter months. Radioactive iodine is not accumulated by the thyroid gland of the hibernating ground squirrel, but 3 days after adrenalectomy the amount of 131I accumulated is equivalent to that taken up by the gland of the non-hibernating animal. The effects of adrenalectomy in the hibernating and non-hibernating ground squirrel are compared with those obtained in hypothermic rats maintained in similar environmental conditions.

Research was performed on four farms, on 2434 highly fertile females Landrace and Yorkshire, and 28 boars of Danish origin, or 7684 consecutive parities, in period 2009-2012. Study of genetic parameters of conventional breeds Landrace and Yorkshire were conducted on 3964 females who mated with 49 males or 15764 litters in the same period. Estimates of genetic parameters for litter size show the same tendency as the legality of the purebred sows that produce 11-14 weaned piglets less per sow per year. Environmental factors, HYS, food technology and management expressed no significant effect on traits. Heritability and repeatability of live and still born piglets, litter size and the live at day 5 after birth and the number of piglets weaned in category of low hereditary traits whose values vary within the limits of 0.07 to 0.12 for the heritability and from 0.15 to 0.19 for the repeatability. There was tendency of lower values of genetic parameters in the conventional compared to highly fertile sows, which is considered to be the effect of selection on gene frequency for the observed traits.