Synergism of microwave acceleration with solvent-free reaction conditions [1-3] is always been interesting to study as it provides an environmentally benign system. Gould-Jacob reaction for the synthesis of quinoline derivatives has been attempted using diethyl ethoxymethylene malonate (EMME) as synthon [4]. Diethyl ethoxymethylene malonate, a versatile reagent is widely used in push-pull alkane [5], 1,4-addition elimination [6], 1,4-addition [7], [3+2] cyclo-additions [8], Diels-Alder reactions [9] and extensively reviewed as Michael reagent [10]. Synthesis of 1,8-naphthyridines, 2H-pyrido[1,2-a]pyrimidin-4-ones, pyrazolinones, pyrons, xanthyrones, guanidine derivatives, 1,2,4-triazoles, 3-oxo-1,2,6-thiadiazines, 8-oxoimidazo[1,2-a]pyrimidines, 3H-pyrrolo[1,2-a]indol-3-one derivatives, 1H-1,4benzodiazepines, pyrido[3,2-e]pyrimido-[1,2-c]pyrimidines have been reported employing EMME [11,12]. Microwave assisted solvent-free synthesis of thieno[3,2-e]-pyrimido[1,2-c]pyrimidines and pyrrolo[3,2-e]pyrimido[1,2-c]-pyrimidines have also been attempted [13,14]. Microwave assisted synthesis have become attractive during last two decades as it is rapid, cleaner, yield increasing and purity enhancing [13-18], sometimes allows solvent-free conditions [1,2,13,14]. It has always been tempting to attend solvent free organic synthesis as it resolves environmental issues [19]. Pyridopyrimidine obtained from EMME also identified as anticancer and antimicrobial agents
