Background: Osteopenia and osteoporosis is a highly prevalent condition and presents a tremendous public health burden. The association of bone disease has been recognized in several diseases of the git, resulting in established guidelines for screening in patients with malabsorptive disorders such as inflammatory bowel disease (IBD) and celiac disease.  Increasingly, the risk of bone disease has been recognized in patients with chronic pancreatitis, who share similar risk factors as patients with other gastrointestinal disorders.Methods: This single-centre study was carried out in Kilpauk medical college. This study population consisted of 47 patients who were image confirmed cases of chronic pancreatitis. History of smoking, alcohol use was taken, body mass index, fecal elastase was measured. Dual-energy X-ray absorptiometry scan was used to examine bone mineral density (BMD) for the lumbar spine and bilateral femoral neck.Results: Of the 47 patients, 19 patients were chronic smokers and 28 patients had history of significant alcohol use. The prevalence of osteoporosis in patient group was 29.8% in patients with CP compared to Indian prevalence of 18.3% in previous studies. The prevalence of osteopenia was 48.9% in patients with CP compared to Indian prevalence of 49.9% in previous studies.Conclusions: Bone disease in CP can be attributed to several risk factors which act synergistically in propagating abnormal bone metabolism. Osteoporosis and osteopenia are underappreciated sources of morbidity in patients with chronic pancreatitis. Bone health management guidelines are urgently required in patients with chronic pancreatitis.

Objective To determine the prevalence of the inlet patch (IP), its clinico-pathological features, and its association with Helicobacter pylori. Materials and Methods A prospective observational study was performed on 1,889 patients referred for esophagogastroduodenoscopy for various reasons, primarily for the evaluation of dyspepsia. All patients were enquired about the presence of symptoms and carefully examined for the presence of IP during upper gastrointestinal (GI) endoscopy. Biopsies were taken from the patients who had IP. Statistical Analysis All statistical analyses were performed using the Statistical Package for Social Sciences (SPSS) 13.0 software for Windows XP. Categorical variables were compared using the chi-squared test or Fisher's exact test and continuous variables were compared using Student's t-test and univariate analysis. A P-value of less than 0.05 was considered to be statistically significant. Results Inlet patches were found in 34 of 1,889 patients (1.8%). H. pylori was identified in 23.52% of patients (8/34) with IP. Gastric H. pylori infection was positive in all (08/08) patients who had IP. Colonization of H. pylori was more common in antral type mucosa (6/8). H. pylori positivity in the IP correlated with globus sensation symptom in our study, 87.5% of patients with IP and H. pylori positive had globus sensation. Conclusion The prevalence of IP seems to be underestimated. H. pylori colonization of the IP is common and it positively correlates with globus sensation and is closely related to the H. pylori density in the stomach. Though preneoplasia within IP is rare, which does not support the recommendation to regularly obtain biopsies for histopathology, it might be beneficial in a subset of patients with persistent globus sensation.