Beta amyloid cleavage enzyme-1 (BACE1) is the key enzyme involved in Aβ peptide formation in Alzheimer's disease pathogenesis. We intend to target this enzyme by exploring benzimidazole analogues against BACE1 as potential anti-Alzheimer agents. Docking studies were performed to determine the hydrogen bond interactions between the designed molecules and the target protein's active site. Research indicates the relationship between oxidative stress and Aβ effect in precipitating neurodegeneration; hence, the series was also studied in vitro to ascertain its neuroprotective role by performing the lipid peroxidation assay. In silico absorption, distribution, metabolism, and excretion studies were undertaken to assess the drug-like suitability of the analogues. To judge the effect of the synthesized analogues on central nervous system (CNS), toxicity and memory model studies were conducted on mice. Thus, overall results showcase analogues 11 and 14 as the most promising ones with the dual role of BACE1 inhibition and neuroprotection, along with memory retention. K E Y W O R D SBACE1, docking, in silico ADME studies, in vitro LPO assay, memory model studies, toxicity study

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Abstract:The study was designed to study the awareness of physical activities among teachers in relation to sex, age and type of school. A self made questionnaire was developed and administered. The data was collected from 100 teachers of secondary level from government, private and public schools. The statistical techniquest-test,χ2 test and percentage analysis were used for the analysis of the data. The results revealed (a) No significant difference in the awareness of physical fitness activities among teachers in relation to their sex; age and type of school (b) No significant difference in the use of physical fitness activities among teachers in relation to their sex, age and type of school.