Neonatal sepsis is a major cause of morbidity and mortality in neonatal intensive care units. Treatment with antibiotics reduces mortality and morbidity, but neonatal sepsis remains a serious life-threatening condition. The objective of this study was to evaluate cognitive impairment in adult mice submitted to sepsis in the neonatal period. To this aim, 2-day-old male C57BL/6 mice were submitted to sepsis by injection of 25 μg of LPS. Sixty days after, the learning and memory were evaluated. It was observed that the mice submitted to neonatal sepsis presented impairment of habituation, aversive, and object recognition memories, and had an increase of immobility time in forced swimming test in adulthood. In conclusion, this study shows that the neonatal sepsis causes long-term brain alterations. These alterations can persist to adulthood in an animal model due to a vulnerability of the developing brain.

OBJECTIVE: evaluated the involvement of NLRP3 inflammasome in schizophrenia-like behavior in young animals exposed to MIA. METHODS: To this aim, on the 15th gestational day, the females received an injection of lipopolysaccharides. When the animals completed 7, 14 and 45 postnatal days, they were killed and the whole brain was dissected for biochemical analysis. Animals with 45 postnatal days were submitted to behavioral tests of locomotor activity, social interaction and stereotyped movements. RESULTS: It was observed that the animals presented schizophrenia-like behavior at 45 postnatal days associated to the increased of NLRP3 inflammasome expression and IL-1β levels on 7, 14 and 45 postnatal days. CONCLUSION: This study show that MIA may be associated with a schizophrenia-like behavior. This behavior can be induced to a neuroinflamatory profile in brain. These evidences may base future studies on the relationship between neuroinflammation and psychiatric disorders.

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This study showed increased activity of Krebs cycle enzymes in cortex, quadriceps, and diaphragm in mdx mice.