The article examines the issues of agricultural production by the agrarians of the Russian Federation in the context of import substitution and their contribution to the formation of food independence in the region. The dynamics of agricultural production in such sectors as crop and livestock production has been analyzed. In recent years, thanks to new innovative technologies in crop production, there has been a positive trend towards an increase in gross harvest, as well as an increase in crop yields. So, in particular, for more than thirty years of the analyzed period of time, gross agricultural production increased by 6110.4 billion rubles, and in the sectors crop and livestock production there was an increase in production by 3276.8 billion rubles. and by 2833.8 billion rubles. These indicators were influenced by such innovative developments in crop production as binary crops, new varieties of agricultural crops, as well as a significant increase in the use of fertilizers on agricultural land.