Serum resolvin D1 levels as a marker of inflammation in constipation dominant irritable bowel syndrome

Background/Aim:The aim of this study was to investigate the role of the platelet-to-lymphocyte ratio (PLR)–neutrophil-to-lymphocyte ratio (NLR) combination, in the prediction of the presence of Helicobacter pylori (HP) and its associated complications in the gastrointestinal system.Patients and Methods:In all, 1289 patients who underwent esophagogastroduodenoscopy and biopsy for HP were included in the study.Results:The ratio of patients with moderate and severe chronic gastritis was higher in HP (+) group than HP (−) group. The ratio of patients with levels 1–3 atrophy and intestinal metaplasia was higher in HP (+) group. Compared with HP (−) group, HP (+) had higher PLR and NLR levels. The ratio of HP (+) patients was higher in high-risk group compared with low- and medium-risk groups. HP invasion stage, the intestinal metaplasia level, and the ratio of patients with atrophy level “3” were higher in high-risk group compared with low- and medium-risk groups. Regression analysis showed that the PLR–NLR combination was an independent risk factor for both HP presence and moderate and severe chronic gastritis.Conclusion:We found the PLR–NLR combination to be a good predictor of HP presence and gastrointestinal complications associated with HP.

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Hepatitis B virus (HBV) infection is the most common viral infectionin the world, and more than 350 million chronic carriers are estimated. 1 The persistence of hepatitis B surface antigen (HBsAg) for more than 6 months is defined as chronic infection. 2 In patients with chronic HBV infection, the annual HBsAg seroclearence is around 0.5%-1%. 2,3 In chronic HBV infection, some individual and viral characteristics such as advanced age, presence of hepatic steatosis (HS), normal ALT levels, negative HBeAg and HBV DNA at the beginning,