IntroductionOrganisms are able to generate organised responses to environmental changes by controlling the level of messenger RNA translation. The ability to respond rapidly allows the mobilization of the host's defences and coordination of innate response to different infections. A large number of microbial pathogens inhibit the translation of host cells. Bacterial and virus infections interfere with protein synthesis of the host and activating or suppressing the innate responses, thus manipulating the translational machinery. Mortality, morbidity and economic adverse effects associated with fungal infections along with the emergence of resistance to antifungal agents make it necessary to gain a better understanding of the pathogenesis and discovery of new agents for treatment of those infections. There is little knowledge regarding the role of translational regulation in fungus-host relationship. The present review aims to show how translation regulation occurs in bacteria and virus infections and shows a mysterious role of translational regulation in the context of fungal infections. ConclusionIn the last few years, incidence of fungal diseases has dramatically