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SUMMARY Metronidazole, a compound widely used in man with minimal side effects, has been shown to be highly active against experimental infections of Clostridium tetani and Cl. welchii in mice. It is too early to forecast what role the compound might have in the chemoprophylaxis of these infections in man.

Study of the diamidines was first directed to MATERIALS AND METHODS protozoal diseases, their usefulness in bacterial infections being discovered subsequently; some of Antibacterial activity our early results on propamidine were cited byOrganisms.-These were derived mainly from the Thrower and Valentine (1943), and its value in Lister Institute

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