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SEVEN FIGURESThe coronary arteries, like the weight, the form, and the histology of the heart, undergo continuous alteration with age. Concerning their macroscopical visible changes Gross ('21) has published detailed investigations. He found that the blood supply to the two ventricles was equal at birth, but that after the first decade the left ventricle was favored. Its supply, he thought, was definitely greater after the third decade, and after the fifth decade, the preponderance in its favor was striking. Consequently, anemia of the right side of the heart took place, which was for the most part relative, the difference depending not so much on the occurrence of degenerative processes as on, diminution in growth, at least in comparison with the left ventricle. He also pointed out the increasing thickness of the left ventricle with growth in comparison with the right. Campbell ('28) repeated Gross's investigations, using the same method, and believed he had verified Gross's results. Gross's contentions did not, as a matter of fact, remain unchallenged. Spalteholz ('24) stated that in his extensive researches he had not observed such changes. Whitten ('30), on the basis of a study of hearts which he treated by the method of corrosion, a method the

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In 87 rabbits, some of which received intravenously at various intervals small, and some large, doses of killed staphylococci, the following findings were obtained. 1. There occurred a hyperplasia of lymph nodes, spleen and thymus, that is to say, a status thymicolymphaticus. This phenomenon is explained as due to immediate local irritation caused by bacteria and their products and by certain "toxins" partly of exogenous, partly of endogenous, origin. 2. The lymphocytosis which appeared was parallel in time and degree with the hyperplasia of the peripheral lymph nodes (axillary, popliteal and cervical lymph nodes) and probably originated in the pseudo-secondary nodules of these nodes. 3. There occurred intense mesenchymal reaction in the vascular connective tissue of the lungs, liver and spleen and after large doses slighter ones in adrenals, kidneys and heart. These reactions correspond with Oeller's adventitial reactions and Siegmund's intima proliferations. In the interstitial tissue of these organs as well as in the walls of the minor vessels proliferations of cells, partly of the type of lymphocytes and plasma cells, partly of that of histiocytes and reticulo-endothelial cells, appeared, which, after large doses, were mixed with many giant cells of Langerhans' type. After small doses lymphocytes and plasma cells predominated, after large doses histiocytes and reticulo-endothelial cells. Because these reactions occurred immediately after the first injection, they can be regarded as primary reactions of the organism to bacteria and their products.

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