No abstract

After implantation of a disc (thickness: 0.25 mm, diam: 1.5 mm) of PUR in the anterior chamber of rabbits through a lancet incision, the reactions of iris, aqueous, and cornea were observed for six months at regular intervals using slit-lamp photography. 'Steeping' materials were as compatible as nonsteeping materials. At the place where the disc touched the iris one could see during a half-year period hyperemia iridis and foreign-substance granuloma of the iris. The cause of these reactions is a toxin in the PUR. Mechanical irritants as a cause could be excluded through the method utilized in the experiment.

No abstract

PVP-iodine was found to be virucidal for adenoviruses and herpes simplex virus in a concentration of 0.5%, i.e., a 1:20 dilution of Betaisodona. Similar concentrations did not delay the healing of corneal epithelium of the rabbit after experimental lesions (Ullerich and Durchschlag, 1953), although the eyes were slightly irritated. However, a higher concentration (1.25%) caused considerable ocular irritation, and healing of the cornea was delayed or completely inhibited. Arginase, which inhibited the multiplication of adenoviruses and herpes simplex virus in cell culture, did not impair corneal healing in solutions of up to 5%.

The biocompatibility and pharmacokinetics of hydroxypropylmethylcellulose (HPMC) 2% (Adatocel) and Tylose 2% (MH 1000) were investigated. A modified anterior chamber implantation test on the rabbit eye is suitable for testing both the biocompatibility and the pharmacokinetics of visco-surgical substances. Both substances were well tolerated. From the fourth day onward, HPMC was no longer detectable in the anterior chamber by infrared spectroscopy.