BOOK REVIEWS lems for two-dimensional and axisym metric flow. He also discusses the known exact solutions and the particular solutions of the Tricomi equation. Various methods of series perturbation expansions, and the transonic similarity rules, are also applied to different types of transonic flow problems. This book, in conjunction wit•h the "Mathematical Aspects of Subsonic and Transonic Cas Dynamics," by Lipman Bel's (Johu Wi ley &: Sous, 1958), should provide anyone a complete background to the t heory of invisdd trausonic flow.

Perturbation solutions for large and for small bearing numbers are developed and applied to steady, self-acting, infinitely long, journal and plane wedge films. Bearing films of this type develop load capacity as a consequence of relative surface motion. The solutions given here have validity for all ranges of geometrical parameters. Four-place accuracy in determining the load carried by a journal bearing is achieved. The plane wedge film solution for large bearing numbers is complicated by the reduction in order of the limiting equation. A boundary-layer type analysis yields fairly accurate results.

The Silencing-Mediator for Retinoid/Thyroid hormone receptors (SMRT) interacts with, and mediates transcriptional repression by, a variety of eukaryotic transcription factors, including the nuclear hormone receptors. The ability of SMRT to function as a transcriptional 'corepressor' is regulated by a variety of signal transduction pathways. We report here that SMRT is a phosphoprotein in vivo, and is also phosphorylated in vitro by unfractionated cell extracts. A major site of phosphorylation of SMRT is a protein kinase CK2 motif centered on serine 1492, and located within a C-terminal SMRT domain that mediates interaction of the corepressor with the nuclear hormone receptors. Phosphorylation of SMRT by CK2 stabilizes the ability of the SMRT protein to interact with nuclear hormone receptors. Our results indicate that SMRT is a member of an expanding family of transcriptional regulators that are modified, and potentially regulated, in response to protein kinase CK2.

No abstract

No abstract