Despite advances in population health, food security, improved sanitation and water quality, and the reduction in poverty, acute enteric infections continue to plague global populations. Advancing utilization of current enteric vaccines is of critical public health importance, as is the development of new vaccines, particularly for enteric pathogens where none currently exist.

Protein antigenResearch data Pneumococcal surface protein A (PspA) Protective aganist multiple pneumococcal serotypes in mice models of invasive disease pneumonia, and colonization. Vaccination of healthy volunteers with PspA generated antibodies aganist multiple strains that protected mice aganist invasive disease. Human studies in progess. Pneumolysins.Pneumolysoids Protection aganist Pneuminia and increased survival after intraperitoneal challenge. human studies in progress Neuraminidases (Nan) Protection aganist colonization and otitis media Pneumococcal surface protein C (PspC) Protection aganist colonization. Protection aganist sepsis Pneumococcal protective protein A (PppA) Protection aganist lung infection. Protective aganist nasopharyngeal colonization. Pneumococcal Histidine Trial Protein D Protective aganist animal models of invasive disease and pneumonia phase II trial reports awaited. IC4 antigens Protection aganist sepsis, pneumonia, nasopharyngeal carriage.