To explore the application effect of nursing intervention guided by King's interactive standard theory in patients with lumbar disc herniation undergoing conservative treatment. Total of 136 patients with lumbar disc herniation admitted to our hospital from June 2019 to May 2020 were randomly divided into interactive nursing group and routine nursing group. The interactive nursing group was given nursing intervention guided by King's interactive standard theory and the routine nursing group was given routine nursing guidance. The disease cognition rate, incidence of adverse behavior, lumbar function and pain degree were compared between the two groups. The disease cognition rates of main symptoms, disease type, familiarity with conservative treatment, necessity of hard bed rest, feasible surgical treatment in severe cases and causes of disease in interactive nursing group were higher than those in routine nursing group (p<0.05); the incidences of standing or sitting for a long time, smoking or bad eating habits, rest on a soft bed, carrying heavy objects, poor compliance and other adverse behaviors in the interactive nursing group were lower than those in the routine nursing group (p<0.05); the range of flexion motion, lateral flexion motion and rotation motion of the interactive nursing group was higher than that of the routine nursing group (p<0.05); after nursing, the visual analogue scale score of the interactive nursing group was lower than that of the routine nursing group (p<0.05). The nursing intervention guided by King's interactive standard theory could improve the disease cognition rate of patients with lumbar disc herniation conservative treatment, reduce their bad acts, improve their lumbar function and relieve their pain.