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Lymphocytes were separated from the parenchymal lung tissue of mice administered either silica or titanium dioxide particles by intratracheal injection. There was an approximately 10-fold increase in the number of T-lymphocytes recovered from silica-treated animals at 2 weeks after injection. This was accompanied by an increase in the percentage of separated cells expressing the interleukin-2 receptor and by enhanced spontaneous DNA synthesis in serum-free culture. No such changes were demonstrable in cells obtained from animals administered titanium dioxide. These results confirm that an influx of T-lymphocytes occurs as part of the early pulmonary inflammatory response to silica particles. Furthermore, lymphocytes in the lung are functionally activated by at least two criteria. Activated T-lymphocytes may play a role in the induction of fibroblast proliferation and collagen synthesis that occurs in silicotic lung disease.

Abstract. Over the last decades, building models have become valuable for a multitude of application scenarios, such as visualisation, simulations and decision support. As the growth of multi-source data consisting of semantic and 2D/3D spatial information, data management becomes feasibility means for facilitating the development and deployment of building model applications. In addition, most studies focus on modelling buildings at geometric level, while semantic analysis can become a promising approach to get a better understanding of built environment. How to utilize multi-source data in a joint manner to further express the building model, therefore, is an emerging challenge. In this paper, we develop a semantic 3D building model based on complex multi-source data. Then, we tackle data management and analysis problems in a geo-database solution for our unified building model. Performance studies on the University of New South Wales (UNSW) campus demonstrate the efficiency of our solution.

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