Synopsis
Binding of Pt-drugs to DNA significantly enhaces base damages, crosslinks, double strand breaks (DSBs) and non-DSB cluster lesions induced by 10 eV electrons. This enhancement of potentially lethal lesions is due to a modification of electron-DNA interactions, which contributes to the synergy between chemo- and radio-therapy, when these modalities are administered in concomitance during cancer treatments.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.