Correcting the sex disparity in access to liver transplantation: Lest perfect be the enemy of betterThe implementation of the model for end-stage liver disease (MELD) as the backbone of liver allocation policy in the United States in 2002 has overall improved waitlist outcomes and standardized access to liver transplantation for patients with end-stage liver disease.However, women experience higher waitlist mortality and lower transplant rates compared with men, attributed in part to underestimation of renal dysfunction by the use of serum creatinine in MELD and MELD-Na. 1-3 Alternative models have been proposed to reduce this gap, including replacement of serum creatinine with estimated glomerular filtration rate or granting additional MELD points to women, but what has been lacking in the literature has been quantification and comparison of the potential impact of these models on the sex disparity itself.In this issue of AJT, Wood et al. compare four scores to determine waitlist priority-the existing MELD-Na, the previously proposed MELD-Na-MDRD and MELD-Na-GRAIL, and a new MELD-Na-Shift-and consider their effect on waitlist outcomes and transplant rates. 4 The authors apply robust statistical methods in a data set
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