The persistent current of interacting electrons in toroidal single-wall carbon nanotubes is evaluated within Haldane's concept of topological excitations. The overall pattern of the persistent current corresponds to the constant interaction model, whereas the fine structure stems from the electronic exchange correlations.
Objectives
In patients with myelodysplastic syndromes (MDS) with >20 transfusions and ferritin levels >1000 μg/L, international guidelines recommend iron chelation therapy (ICT). The study's objective was to determine guideline adherence and the intensity of ferritin monitoring in clinical practice.
Methods
We performed an observational population‐based study using the HemoBase Registry, which contains data of all MDS patients diagnosed since 2005 in Friesland, the Netherlands. Clinical information on transfusions, ferritin measurements, ICT, and clinical performance as defined by age ≤ 80 years, Charlson Comorbidity Index <2 and lower‐risk MDS was collected from health records.
Results
Two hundred and thirty seven of 292 patients (81.1%) received ≥1 transfusion, and 121 (41.4%) received >20 transfusions. In 57 of these 121 patients (47.1%), ferritin measurements were performed at least once. Clinical performance was significantly associated with monitoring ferritin around the 20th transfusion (RR: 2.49, p = .016). Clinical performance was also associated with initiating ICT (RR: 5.99, p < .001). ICT was offered to 22.3% (n = 25) of eligible patients.
Conclusions
In this population‐based study, ferritin levels were measured in <50% of MDS patients who received >20 transfusions, and clinical performance was significantly associated with measuring ferritin. Our study suggests that in heavily transfused MDS patients, ferritin monitoring is primarily based on patients' clinical performance rather than guideline recommendations.
C'est en effet le cas. Les derniers se comportent comme des substances avec une liaison double, (qui ne se trouve par sous l'influence dun groupe CO) et l'oxydation des deux liaisons doubles a lieu sans grandes differences de la vitesse, les premiers &ant attaques d'abord tres vivement, tandis que la reaction se ralentit brusquement du moment ou la moitie de l'insaturation a disparue Dam le cas oti nous avons affaire A un systeme de trois liaisons doubles conjuguees un tiers de l'insaturation a disparu apres env. 3/4 d'heure, deux tiers apres un jour. tandis que la reaction prend alors une marche extremement lente. En revanche, en prenant un grand ex& du peracide, les acides A systeme conjugue consomment plus de l'oxydant que la quantitee calculee, les acides A liaisons doubles isolees fixent au-contraire precisement la quantite thtorique.C e caractere diffirent des deux esptkes de substances insaturies nous donne dans l'acide peracgtique un rnoyen trPs simple pour les distinguer les uns des autres.Partie experimentale.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.