In two groups of patients with well-defined obstructive lung disease – a group of bronchitics according to WHO criteria and a group of patients with extrinsic allergic asthma – the effect of carazolol, a so-called non-cardioselective β -blocking drug, was investigated. Pindolol was used to compare the results with a second blocking drug. Carazolol increased bronchial resistance in the bronchitic group but not in the asthmatic group; with the exception of 1 patient in whom carazolol induced a status asthmaticus. The effect of the drug on bronchial resistance depends only in part upon the drug itself, but was influenced much more by the characteristics of the patients. We therefore conclude that the quality of β₁-receptorspecificity was, at least in part, a result of the qualities of the patients. The designation of a drug as β₁-specific should therefore be used very cautiously. Serious side-effects on the bronchial system in particular persons are also possible from drugs shown to be safe in some groups of patients

The main aim of this study was to investigate whether a new slow-release formation of nicardipine can control hypertension and whether its antihypertensive effect is manifest throughout the dose intervals. In a randomized, double-blind placebo-controlled study, the antihypertensive effect of two calcium antagonists (Type II) was investigated in two independent groups of hypertensive patients with coronary artery disease. One group of patients received 40 mg nicardipine slow-release b.i.d. and the other 20 mg nifedipine slow-release b.i.d. The effect of the active drugs on blood pressure (BP), heart rate, and hemodynamics was compared with placebo within each group. In addition, a group comparison was made to establish whether nicardipine had any advantage over nifedipine. Twenty-eight patients [27 female, 1 male; 55 (41-72) years old], 18 with previous myocardial infarction (MI) entered the study (nicardipine, 15 patients; nifedipine, 13 patients). A placebo period of 3 days was followed by a 13-day drug treatment period. From the first to last trial day, BP and heart rate were measured three times daily. At the end of the placebo and the active drug periods, the following measurements were carried out: ambulatory BP monitoring by half-hourly recording for 12.5 hours with the Remler system, ergometric tests with ECG, and right heart catheterization. Both drugs lowered the BP at rest, during exercise, and during usual daily activities. The antihypertensive effect of nicardipine was significant for the daytime mean arterial BP (MAP) and for systolic BP and diastolic BP at various stages of the exercise tests. The difference between the effect of nicardipine and nifedipine was not significant.(ABSTRACT TRUNCATED AT 250 WORDS)

No abstract