A prospective study on gastric biopsies with follow up of patients was needed to assess the incidence and distribution of intestinal metaplasia

Seven patients with perianal and anorectal giant condyloma acuminatum (Buschke-Loewenstein tumour) are presented. In five of these patients histopathological examination of the lesions disclosed varying degrees of dysplasia and/or squamous carcinoma. The clinicopathological features and aetiology of perianal and anorectal condylomata acuminata, giant condyloma acuminatum and verrucous carcinoma are discussed. The viral induction and malignant transformation of these papillomatous squamous lesions are emphasized.

No abstract

SUMMARY A case of fibromatosis of the breast in a 65-year-old woman is described. The difficulties in the histological and cytological differential diagnosis of fibromatosis in such an uncommon site are emphasised.Among the benign mesenchymal lesions of the breast masquerading as clinical carcinoma, fibroblastic and fibrous proliferations such as fibromatosis are fairly rare. Their inflammatory, reactive, or truly neoplastic nature is often difficult to determine histologically, and the cytological features of fineneedle aspiration from these lesions may also be misleading.We report the case of a 65-year-old woman with an unusual fibroblastic proliferative lesion of the right breast of three years' duration and with the features of an infiltrative fibromatosis. We emphasise the problems of differential diagnosis, histogenesis, and cytological aspects of fibromatosis of the breast. Case reportA 65-year-old postmenopausal woman, para 8, was admitted to our institution in July 1979 for investigation of a mass in the right breast. The patient stated that she had first noticed this mass about three years previously after a minor trauma to the right breast when she was hit on the chest by the fall of concrete material from a ceiling. At the time of injury the patient had not noticed skin bruising of the right breast. Before the present hospital admission the mass had been increasing in size and had become somewhat tender with a slight 'milky' discharge from the right nipple.On physical examination both breasts were pendulous, and a firm and movable 4 x 4 cm painless mass was palpable in the lower inner quadrant of the right breast. Although the area of the skin overlying this mass was slightly depressed, there was no skin fixation or nipple retraction. The left contralateral breast appeared normal. Axillary lymph nodes were not felt. The liver was not enlarged. There was no history of previous surgery.

Collagenous colitis and lymphocytic colitis (previously described as microscopic colitis) are two newly recognised forms of colitis. Both have generated much controversy and continue to do so; their aetiology and pathogenesis are unresolved and their association with a variety of immune-related disorders is intriguing. Response to available therapeutic modalities is often disappointing. The possible relationship or overlap between these two conditions remains a controversial issue. The aim of this review is essentially to present an overview of collagenous colitis and lymphocytic colitis and to propose an unifying concept with an adapted terminology.