Varicose veins (VV) in the lower limbs are the most prevalent vascular condition in humans. They can cause significant signs and symptoms and, in extreme cases, death. This study aims to investigate the prevalence and identify the risk factors for varicose veins among nurses working in multiple departments at Jazan King Fahd Central Hospital and Prince Muhammad bin Nasser Hospital. A cross-sectional study was conducted by sending a questionnaire to female and male nurses in these hospitals. This study included 482 nurses, 415 (86.1%) of whom were female and 67 (13.9%) male. The prevalence of varicose veins among the nurses of both hospitals was 76 (15.8%), compared with 406 (84.2%) not diagnosed with varicose veins. The prevalence of varicose veins was 67 (88.2%) in female nurses, compared with 9 (11.8%) in male nurses. The risk factors associated with varicose veins were ethnicity ( p = 0.007), carrying heavy items ( p = 0.001), lack of exercise ( p = 0.031), family history ( p = 0.001), use of hormonal therapy ( p = 0.001), use of contraceptive pills ( p = 0.0035), type of delivery ( p = 0.002), number of children ( p = 0.004), and hours sitting per shift ( p = 0.002). The comorbidities associated with varicose veins were deep vein thrombosis ( p = 0.001), hypertension ( p = 0.002), chronic constipation ( p = 0.006), diabetes ( p = 0.001), kidney disease ( p = 0.001), rheumatoid arthritis ( p = 0.001), coronary artery disease, and severe occupational injury to the lower extremities ( p = 0.001). Nurses are responsible for most of the health system's services. Increasing the number of nursing workers for patient care, encouraging physical exercise, and lowering the pension age appear to be required to avoid the occurrence and development of varicose veins among nurses.