Halas Cissus Rotundifolia)vitaceae). has been widely used as an traditional medicine in Yemen. This study was designed to assess the efficacy and safety of three doses of Cissus Rotundifolia fruits powder (CRFP) compared with glibenclamide. Hypoglycemic effects of CRFP were also investigated on alloxan-induced diabetic rabbits. CRFP and the standard drug glibenclamide were orally administered daily to diabetic rabbits for four weeks. Blood glucose levels were determined. The oral administration of CRFP didn't cause any signs of clinical abnormalities in the treated rabbits. Thus the given dose of drug appears to be safe. CRFP (1, 2 and 3 g/kg.p.o) showed a significant reduction (P< 0.05) in blood glucose level in 30 days. A maximum reduction of blood glucose level was occurred at the dose of 3 g/kg. phytochemical analysis indicated that Cissus rotundifolia fruits contains Fibers,protein,lipids,hydrolyzable carbohydrates,soluble sugars, free aminoacids,phenolic,tannin,anthocyanin,carotenoid,VitaminC,Vitamin A ,Macroelements, Microelements, Essential Amino Acids and Non-Essential Amino Acids.

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