Molecular studies have proven beneficial in understanding the pathophysiology of PD. Besides, the advancing application of zebrafish as a PD model has enabled researchers to conduct molecular studies with more promising outcomes and significance. Current evidence reported on the association of HMGB1 protein with neuroinflammation-induced PD pathogenesis. However, to the extent ofour knowledge, the molecular mechanism pertaining to HMGB1 involvement in PD are still elusive. Hence, we propose to conduct a study on HMGB1 protein, to elucidate its role in the pathogenesis of the MPTP-induced zebrafish model of PD. This study will answer the question pertaining to the involvement of HMGB1 in PD development and whether the knockdown of this protein can improve PD symptoms in zebrafish, particularly MPTP-induced motilitydisorders.

Africa is marked by a higher frequency of illnesses, trauma, and violence, as well as greater exposure to toxic substances and malnutrition, against a backdrop of far greater genetic variety. All these variables present potential for the neuroscience community in Africa to achieve breakthroughs in fundamental research and develop personalized therapies to boost brain health and well-being throughout the continent. While the high incidence of mental, neurological, and substance-use problems presents unique challenges to the African neuroscience community (Feigin et al., 2017; Feigin et al., 2019), the possibilities are also equally great. For instance, low physician-to-patient ratios expose the average clinician to a high number of patients, hence enhancing possibilities for field-specific competence development. This increased clinical exposure generates topics of study that are directly relevant to the local community, and improves the viability clinical studies, which helps not only the African community, but also the Global North. Recruiting participants for clinical studies on traumatic brain injury, for instance, takes less time in Africa than in Europe. Lastly, there is ample opportunity for clinically oriented neuroscience research to enhance healthcare in Africa, particularly for young people. Specific objectives include the improvement of developmental potential and mental health, as well as the alleviation of mortality and neurological impairment.

Telemedicine is the term used to describe the use of technology to provide medical care over a distance. Telephone, email, and real-time videoconferencing are the most frequently used telepsychiatry technology. Telemedicine has been used to provide simple and efficient healthcare solutions in the treatment of illness. Despite it is relatively new, mobile health (mHealth) has grown significantly in popularity as a means of assisting persons living with a chronic condition. The current study reviewed existing mobile health dementia applications from different perspectives. These applications could include a variety of strategies and resources to assist the community especially in caring for individuals with Alzheimer's disease.

This is a CASE STUDY OF MULTIPLE SCLEROSIS (MS) is designed to be a PBL for teaching for Medical students.

This is a case report for a child with seizures. It is presented as a PBL for teaching purposes in Medical School for Undergraduate Medical Students