The AgNPs-IPN's has been successfully prepared by synthesized biosynthesis of Ag nanoparticles (AgNPs) from Zizyphus Spina Christi L leaves extract and then linked with polymer network derived from cured epoxy with lignin to produce (AgNPs-IPN's) and characterized by using X-Ray, FTIR, TGA, DTG, SEM, and TEM surface morphology analysis and then used as adsorbent of methylene blue dye from synthetic wastewater. Parameter like pH, contact time, methylene blue concentration, and adsorbent dose concentration was studied. Methylene blue removal increased when the dosage of biosorbent increases. Isotherm adsorption was also described by the Langmuir and Freundleich models, It was found that Langmuir isotherm (R 2 = 0.9956) is better than the Freundlich model (R 2 = 0.9937) which implies that the adsorption of MB on AgNPs-IPN's was monolayer. Thus the maximum adsorption capacities calculated from the Langmuir model was found to be 33.5 mg.g −1 and was consistent with the experimental data. The synthesized AgNPs-IPN's showed an excellent activity towards the removal of methylene blue from synthetic wastewater.