Aims:To evaluate the effect of local irrigation with tranexamic acid in minimizing post-operative bleeding following the removal of impacted lower wisdom teeth. Materials and Methods: This clinical trial was conducted at the Department of Oral and Maxillofacial Surgery / College of Dentistry / University of Mosul. The sample recruited comprised twenty healthy subjects who required surgical removal of clinically as well as radiographically evident impacted lower wisdom teeth. The sample was subdivided into two groups of ten subjects each. The first group which is the control group included ten subjects where after removal of the tooth, local irrigation of socket was carried out with normal saline. The second group which is the trial group comprised ten subjects also, but in which tranexamic acid (injectable solution) in diluted form was used for local irrigation of socket. Both solutions were of equal amount. Estimation of amount of blood loss immediately following surgery was the criterion for comparison and was based on weight of gauze used before and after application over extraction socket. Results: The results showed a statistically significant decrease in the amount of blood loss in the trial group when compared with the control group. Conclusions: Tranexamic acid as commercially available or freshly prepared oral rinse may be used as an aid for the reduction or prevention of postoperative bleeding following the removal of third molars in healthy subjects as well as in patients with bleeding problems.

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The aim of this study is to examine analgesic effect of Coenzyme Q10 ointment in mice. Fifteen healthy male albino mice were selected for this study. The animals were divided into three groups of five animals for each group. The pain reaction time was recorded pretreatment for each animal and was taken as a basal threshold(1). Group 1 served as a control and was applied Vaseline ointment topically on fore and hind limb. Group 2 and 3 were applied topically Coenzyme Q10 ointment 4%, 8% respectively on fore and hind limb. The onset and duration of analgesic effect of Coenzyme Q10 ointment were evaluated in mice by utilizing a Hot-Plate test at 55±1˚C. Latency reaction time was recorded after 3min. and (10-60 min) after ointment applied. The prolongation of latency times compared with the values of the control was used to express about analgesic effects of Coenzyme Q10 ointment and the percentage of antinociceptive ,Maximal Possible Effect (MPE) was calculated. The Coenzyme Q10 ointment at concentrations (4%, 8%) produced analgesic effect in mice after 3 min, respectively in comparison with control. The percentage of maximum possible effect (MPE) was significantly increased in group treated with (4%,8%) Coenzyme Q10. It can be concluded that, the Coenzyme Q10 ointment have a good analgesic activity in mice after 3 minutes of topical application and prolong the duration of analgesia more than 40 minutes depending on concentration of Coenzyme Q10 ointment. ‫ـــــــــــــــــــــــــــــــــــــــــ‬

Aim: To estimate the importance of time in determining the difficulty of surgical removal of impacted third molars. Materials and Methods: Two hundred medically fit patients were selected with an age range between 18-25 years of both sexes. These patients had vertically impacted lower third molars and indicated for surgical extraction. The diagnosis of third molar impaction was based on clinical and standard intraoral periapical radiographs. A double-blind approach was adopted whereby two researchers carried out a classification of the operation based on expected time of surgery and the third researcher performed the surgery. The classification of the impaction was performed pre-operatively according to Pell-Gregory classification, then the operation was performed following the standard procedure for this type of surgery. Following extraction, surgical difficulty was rated according to Garcia et al. classification and operation time from the incision till suturing of the flap. Results: Comparison among the three classification systems was performed and the results indicated no significant difference among the three classifications regarding simple and moderate operations, but only a significant difference was recorded for the difficult operations. Conclusion: This study, however, revealed the importance of time in assessing the difficulty of such operations and this, in turn, will help surgeons in scheduling the treatment plan and taking the necessary precautions when dealing with difficult operations.