Résumé -Abstract -Oral Kaposi sarcoma after renal transplantation: a case report and review of literature. The immunosuppressive therapies are associated with an increase in the risk of Kaposi sarcoma among transplant patients. The management of these tumours is challenging as the immunosuppression must be monitored to prevent a potential transplant rejection. In 2009, a 48-year-old patient was referred to us by the nephrology department for a suspicious palatal lesion. The patient having had a renal transplantation in 2008 was under immunosuppressants. The intra-oral examination revealed a right red-purple palatal swelling, of 2.5 cm in long axis, painless, with firm consistency on palpation. The buccal vestibule was clear. No satellite adenopathy was observed. A biopsy revealed Kaposi sarcoma. An assessment of the local and general extension concluded an absence of an underlying osseous involvement as well as other remote locations. The treatment consisted of a modification of immunosuppressants associated with tumor resection surgery. The loss of mucous substance was repaired by an advanced vestibular flap and rotational palatal flap. The histology confirmed the diagnosis of Kaposi sarcoma and the limits of curative surgery. A 14-month follow-up showed a favorable evolution. Local and regional monitoring did not reveal any recurrence signs; this was confirmed by CTscan follow-up examination. Subsequently, the patient underwent a prosthetic restoration by means of a removable partial denture.