The application of scientific approach in the student-centred learning process requires the role of the teacher as a facilitator to support the creation of active learning by using a variety of media. One way to create such learning is to use e-module media based on learning cycle 7E. The purpose of this research was to find out the effectiveness of scientific approach by using e-module based on learning cycle 7E on high-school-students' learning outcomes. The research was an experimental research using one-group pretest-posttest pre-experimental design. This study used a sample of Mathematics and Science (MIA) students of Senior High Schools in Karanganyar Regency, Central Java, Indonesia. The sampling technique used was purposive sampling while the data-collection technique was using test, that are pre-test and post-test. The data test were then analysed using t-test (Independent Simple t-test) with SPSS 17.0. The results of the analysis showed that the application of scientific approach using E-Module based on learning cycle 7E is effective to use.