This paper proposes an on-line adaptive digital Proportional Integral Derivative (PID) control algorithm based on Field Programmable Gate Array (FPGA) for Proton Exchange Membrane Fuel Cell (PEMFC) Model. This research aims to design and implement Neural Network like a digital PID using FPGA in order to generate the best value of the hydrogen partial pressure action (PH2) to control the stack terminal output voltage of the (PEMFC) model during a variable load current applied. The on-line Particle Swarm Optimization (PSO) algorithm is used for finding and tuning the optimal value of the digital PID-NN controller (kp, ki, and kd) parameters that improve the dynamic behavior of the closed-loop digital control fuel cell system and to achieve the stability of the desired output voltage of fuel cell. The numerical simulation results (MATLAB) package along with the schematic design experimental work using Spartan-3E xc3s500e-4fg320 board with the Xilinx development tool Integrated Software Environment (ISE) version 14.7 and using Verilog hardware description language for design testing are illustrated the performance enhancement of the proposed an adaptive intelligent FPGA-PID-NN controller in terms of error voltage reduction and generating optimal value of the hydrogen partial pressure action (PH2) without oscillation in the output and no saturation state when these results are compared with other controllers.