No abstract

No abstract

Summary. The transfer of intravenously injected enzymes from blood to Thiry- Vella fistulas of the small intestine was studied in dogs. The enzymes used were highly purified preparations of glutamic-pyruvic transaminase and two glutamicoxalacetic transaminases. The rate of transfer varied greatly, depending on whether isotonic or hypertonic solutions were placed inside the loop. On the other hand, there was relatively little difference in the transfer of the three enzymes, although their plasma-disappearance half-fives varied from 2.6 days to less than 1 hour. Quantitative estimates indicate that this pathway, which appears to represent nonspecific transudation across the intestinal mucosa, contributes relatively little to the metabolic clearance of the three enzymes, in contrast to the clearance of a serum protein. Zymosan, which had been found earlier to inhibit the metabolic clearance of enzymes apparently because of its blocking effect on the reticuloendothelial system, was without effect on the intestinal clearance of the enzymes. A slower but significant transfer of enzyme was also noted in the direction of intestine to blood.

No abstract

No abstract