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Background: Obesity is one of the most common noncommunicable diseases and public health issues in the world at every stage of development. The World Health Organization (WHO) estimates that 13% of adults worldwide are obese. Aim of the Work: To investigate the relationship between-243A>G polymorphism of GAD2 gene and the presence of obesity. Subjects and Methods: The present case-control study included thirty (30) obese patients with BMI ≥30 kg/m². In addition, twenty (20) age-and sex-matched healthy subjects served as a healthy control group with BMI <25 kg/m². All subjects were genotyped for the GAD2 gene SNP-243 A>G (rs2236418) using PCR-RFLP technique. The study was approved by the