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SummaryRabbit antibodies to hsp58 (PI), the human homologue of the Escherichia coli stress protein groEL, react specifically in indirect immunofluorescence and complement-dependent microcytoxicity experiments with a cell surface antigen expressed constitutively by T cell lines bearing y/b receptors.This anti-hsp58-reactive antigen is not demonstrable on T cells that express a/0 receptors or on various cells that lack T cell receptors. Certain evidence was obtained to suggest that the target antigen on the surface ofy/b T cells is a ti77-kD protein distinct from intracellular hsp58 and known members of the hsp70 stress protein family. While the exact nature and significance of this anti-hsp58-reactive protein remain to be determined, these data may help to clarify the roles of groEIrrelated stress proteins and -y16 cells that recognize groEL homologues in immunologic defense against infection and in autoimmune disease .

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