The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

Experiments have been described which show the very high sensitivity of the isolated perfused guinea pig heart preparation in the estimation of plasma levels of catecholamines after intravenous infusion in dogs. It was observed that crude plasma samples show the same pattern of positive inotropic response as extracts of these samples. By means of the isolated guinea pig heart method, the presence of circulating catecholamines could still be detected 30 minutes after the end of infusion. The observation that dichloroisoproterenol may block the positive inotropic effect of epinephrine, while only slightly reducing the positive inotropic effect of norepinephrine, may be used to differentiate between these two catecholamines.

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Cholesterol when administered chronically in large amounts depressed the blood ascorbic acid content of cells or plasmas, or both, in rabbits and guinea pigs. Ascorbic acid administered simultaneously with cholesterol seemed to reduce the effect of the cholesterol. Acutely, ascorbic acid administration caused hypercholesterolemia in rats (noted also in other laboratory animals and in humans). It is suggested that hypercholesterolemia following ascorbic acid administration may result from liver release of cholesterol, which may be related to adrenal hormone action.