Dentifrices containing H 2 O-reactive bioactive glasses alleviate hypersensitivity in teeth via the blockage of open dentinal tubules. Here, the ability of two such products to release Ca 21 ions into human saliva was investigated, together with their influence on the status of this biofluid's 1 H NMR-detectable biomolecules. Human salivary supernatants were equilibrated with increasing volumes of those derived from each dentifrice (5.00 min at 378C). These biofluids were also equilibrated at 378C with a preselected quantity of the intact products (samples were collected at increasing timepoints