The RID assay is one of the in vitro methods used for in-process control in the production of rabies vaccines for veterinary use. It has been shown to be very useful for determining antigen concentration in the final bulk product. The work presented in this paper, including the production and standardization of candidate standard reagents for use in the Radial Immunodiffusion Assay (RID) was carried out at the Pan American Institute for Food Protection and Zoonoses (INPPAZ/PAHO/WHO). The study was completed with the cooperation of the Faculty of Veterinary Sciences, National University of La Plata (NULP), Argentina, where the validation of the proposed standards and the quality control of samples from 28 different batches of rabies vaccines produced with Pasteur strain rabies virus (PV) in BHK cells were performed. The activity of the vaccines was determined by in vivo (NIH) and in vitro (RID)assays. The results of the candidate reagents for the reagent standardization tests showed stability, sensitivity and reproducibility. The Relative Potency the 1.2 between the problem vaccines and the reference vaccine was estimated by variance and regression analysis. The results of our validation study show that the INPPAZ (PAHO/WHO) is capable of producing and distributing the above-mentioned standard reagents, as well as of providing support for the incorporation of the RID technique (sensitive, rapid and inexpensive) to the laboratories that manufacture rabies vaccines in Latin America and the Caribbean.

El control del desempeño, especialmente en los procesos de gestión empresarial y tributaria, obliga a las organizaciones a emplear herramientas con orientación estratégica como parte fundamental en su estructura. El objetivo de la presente investigación consistió en diseñar un cuadro de mando integral como herramienta estratégica que permite medir, evaluar y controlar el cumplimiento de las normas tributarias nacionales, amparadas en las reglas comunes planteadas en la Norma Internacional de Información Financiera (NIIF). Para ello se realiza un análisis descriptivo a partir de evidencia bibliográfica sobre la temática abordada; además se presentan resultados de un diagnóstico organizacional in situ que expone las principales falencias que están presentes en la organización, del que se propone un cuadro de mando integral para la organización con principal énfasis en la perspectiva financiera. Se concluye la importancia de implementar el cuadro de mando integral, para el cumplimiento de objetivos de gestión y tributarios alineados a los objetivos estratégicos de la organización, como una herramienta eficiente de medición del desempeño estratégico de las organizaciones.

Abstract-

The feasibility of the using of mucilages as viscous hydrocolloids in order to reduce dependence on inorganic products that are unfriendly to the environment, is a necessity that the scientific community must take advantage on behalf of development of new products. The aim was to determine the phytochemical components and thickening capacity of mucilage as a hydrocolloid in a shampoo formula. Phytochemical sieve was done by coloration, precipitation and flotation reactions. Mucilage extraction was performed by hydration-maceration of crushed stems according to experimental design  (three factors and two levels) and controlled by the viscosity response variable. For the shampoo, a design of  was used (two factors and two levels), evaluated with viscosity response variables and lather formation, results that were tabulated with the statistical software statgraphics plus. The results show in the hydrocolloid the presence of tannins, alkaloids, triterpenes. Its thickening capacity due to the significant viscosity of the hydrocolloid (1186 mPa.s). The viscosity of the shampoo between 1020 and 1460 mPa.s and the amount of foam (213 ml) that reward the quality. It is concluded that, the complex molecular structure and abundant presence of mucilage in its natural state in the stems of Malachra alceifolia Jacq allows the hydrocolloid obtained to have a great viscosifying and moisturizing capacity with an almost neutral pH, qualities that affect the quality of the shampoo and are suitable for commercial products with friendly features to the environment; being promoted as a raw material for formulations of other personal hygiene products with an important projection of immediate application in the pharmaceutical and cosmetic industry.

No abstract