The learning curve to using e-cigs has important implications for laboratory tests of these devices with novice users. Similarly, the multiple e-cig options and the use of "mods" create challenges for researchers and policy makers. Transdisciplinary research is urgently needed, and experienced "vapers" are very interested and willing research participants.

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Nicotine delivery may depend on vaping technique, particle evolution, and cloud effects. Predicted 10% arterial and 15% venous delivery may describe bystander exposure better than vapers exposure.

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Women often substantially overestimate their chances of getting breast cancer. Educational intervention by a physician, including explanation of an individual's calculated risk, can reduce this error. The effect of education appears to persist at least for several months.