number, and course of regimens, and survival after OC using Kaplan-Meier method were analyzed. There were 12 males and 6 females with a median age of 59 (range 13-83) years. Histological subtypes were 13 osteosarcomas, 2 MFHs, and 3 others, and all patients except one had metastasis. The median follow-up period after OC was 10.7 (1.2-135.3) months. Results: Median period from first visit to OC was 23.7 months. OC was performed as first line in 1, second line in 9, and third line in 8. Median regimens and courses of OC were 1(1-4) and 4.5 (1-30), respectively. OC regimens included CBDCA/ETP (median 9 (3-17) courses) in 11, GEM/DTX (median 2 (1-4) courses) in 7, THP (median 2.5 (1-18) courses) in 6, and DXR (median 1 (1-2) courses) in 3. Additional treatments were radiation in 7, surgery in 2, and carbon ion radiotherapy in 1. Median survival after OC was 19.8 months in 15 patients without radical treatments. Three patients were treated with surgery or carbon ion radiotherapy, and 2 of them survived 9 years or longer. Conclusion: Metastatic bone sarcoma patients are known to have poor survival. OC is a desirable treatment for them because daily life can be maintained, but approved drugs are few in Japan. In our study, survival after OC was acceptable even for patients without radical treatments, and the regimen of CBDCA/ETP was usable for a long time. OC may thus be a good treatment option for advanced bone sarcoma patients. O3 À 6 À 4 A qualitative study of user perspectives on using medication administration information system in oncology wards

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Droplet-based transport driven by surface tension has been explored as an automated pumping source for several biomedical applications. This paper presented a simple and fast superhydrophobic modify and patterning approach to fabricate various open-surface platforms to manipulate droplets to achieve transport, mixing, concentration, and rebounding control. Several commercial reagents were tested in our approach, and the Glaco reagent was selected to create a superhydrophobic layer; laser cutters are utilized to scan on these superhydrophobic surface to create gradient hydrophilic micro-patterns. Implementing back-and-forth vibrations on the predetermined parallel patterns, droplets can be transported and mixed successfully. Colorimetry of horseradish peroxidase (HRP) mixing with substrates also reduced the reaction time by more than 5-times with the help of superhydrophobic patterned chips. Besides, patterned superhydrophobic chips can significantly improve the sensitivity of colorimetric glucose-sensing by more than 10 times. Moreover, all bioassays were distributed homogeneously within the region of hydrophilic micropatterns without the coffee-ring effect. In addition, to discuss further applications of the surface wettability, the way of controlling the droplet impacting and rebounding phenomenon was also demonstrated. This work reports a rapid approach to modify and pattering superhydrophobic films to perform droplet-based manipulations with a lower technical barrier, higher efficiency, and easier operation. It holds the potential to broaden the applications of open microfluidics in the future.