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This study describes and analyzes the general aspects, application techniques and side effects of the use of hyaluronic acid in aesthetic biomedicine. Taking into account that aesthetics is factually one of the most powerful segments of the economy, there is a huge demand for aesthetic procedures to alleviate body and facial disorders. Contemporary society is increasingly concerned with maintaining a youthful and harmonious appearance, leading to the constant search for methods that soothe or delay the expression of these signs, thus remaining with the appearance of young skin for a longer time. Currently, the use of fillers in aesthetics has expanded considerably. Becoming a tool every time, but used to aid rejuvenation. There are currently many different types of fillers, however there is no ideal, pure filler on the market without adverse effects. Among the fillers, hyaluronic acid (HA) is the closest to these expected peculiarities, for this reason it is the one that has been most used, however it is emphasized that it can have some adverse effects. The present study aimed to describe and analyze the general aspects and techniques of application of hyaluronic acid in aesthetic biomedicine, expose its risks and list its possible complications. To this end, a bibliographic search was carried out in the main databases, the virtual health library (bvs); scientific electronic library online (scielo), academic Google and lilacs. Concluding then that HA is an effective and relatively safe alternative for several uses in aesthetic biomedicine.