Under the background of teaching requirements comprehensively satisfied by information hardware, clarifying the influencing factors of teaching behaviors on student activities in the information-based teaching, as well as the influence mechanism. In this paper, a mediator model was established. Next, the collaboration degree in the teaching process was taken as the influencing factor and information monitoring was used as the mediating variable to discuss the effect of teaching behaviors on student activities in the classroom teaching process. Subsequently, the structural equation model (SEM) was used to mine the relationship between teaching behaviors and student activities and the influence on student activities. It was discovered that the overall Cronbach’s a value of questionnaires was 0.920, indicating a favorable questionnaire reliability; the KMO value was 0.916, which represents excellent questionnaire validity; three factors—teachers’ teaching behaviors, collaboration degree, and media monitoring—have shown positively strong correlations with student activities. The research results have provided realistic examination for enriching information-based classroom factors like teaching concepts, teaching resources and teaching quality, mine the existing problems and further provide reform orientation for promoting the high-efficiency development of information-based teaching, completing the effective engagement between information technology and specialized courses, and integrating abundant information-based teaching resources.