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cytometry and ADP-induced platelet aggregation (PAG), measured by light transmission aggregometry]. Results: All the subjects were dichotomized according to PRI medians (normal-responders: PRI<41.85%, n¼45 and low-responders: PRI>41.85%, n¼45) and PAG medians (normal-responders: PAG<65.5%, n¼49 and low-responders: PAG>65.5%, n¼41). No significant differences of demographic data were found between normaland low-responders determined by the two methods. To further explore the potential clinical characteristics associated with the discrepancy of VASP phosphorylation and PAG in evaluating platelet reactivity, patients who were normal-responders to both methods, or who were low-responders to both methods, were defined as "concordance" group (n¼60). Otherwise, the rest patients were defined as "discrepancy group" (n¼30). Stepwise binary logistic regression analysis revealed that among factors that potentially influence the consistency of the two methods, smoking was the only independent predictor associated with the discrepancy of the two methods (OR 3.333, 95% CI 1.120 to 9.917, P¼0.030). After adjusted by the traditional factors (age, gender, hypertension and diabetes) that may influence the responsiveness of platelets to clopidogrel, smoking remains statistically predict the discrepancy between these two methods in evaluating platelet reactivity (OR 4.399, 95% CI 1.105 to 17.522, P¼0.036).Conclusions: The present study shows that smoking is an independent factor that influences the consistancy of VASP phosphorylation and ADP-induced PAG in evaluating high on-clopidogrel platelet reactivity in patients with STEMI. GW25-e4386The platelet receptor P2Y12 gene polymorphisms and thrombelastography could predict the risk of bleeding events in clopidogrel-treated Chinese patients after percutaneous coronary intervention