Cement-containing mineral powder can effectively improve the moisture stability of an asphalt mixture; therefore, this study systematically summarizes the research status of cement–mineral fillers on the performance of an asphalt mixture and determines the limitations of related studies. In this study, long-term performance tests of styrene-butadiene-styrene- (SBS)-modified asphalt mixtures are designed and evaluated with different blending ratios of the cement–mineral powder under three aging conditions. Moreover, the effect of the cement–mineral composite filler on long-term performance of the asphalt mixture using different blending ratios is determined. Cement improves the high-temperature performance and water stability of asphalt mixtures, but only for certain aging conditions. Considering the regulations for the road performance of asphalt mixtures for three aging conditions, as well as long-term performance considerations, the results indicated that the mass ratio of Portland cement to mineral powder must not exceed 2:2. Low-temperature bending and splitting tensile tests confirmed that an excessive amount of cement filler will embrittle the modified asphalt mixture during long-term aging, thereby deteriorating the tensile properties. The mechanism by which the filler influences the performance of the asphalt mixture should be further studied from the perspective of microscopic and molecular dynamics.