Aims: Genetic variations in DNA repair genes may impact repair functions, DNA damage, and breast cancer risk. This study is aimed to assess the associations of genetic polymorphisms in excision repair cross-complementing group 2 (ERCC2) with the risk of developing breast cancer. Materials and Methods: In total, 101 histopathologically confirmed breast cancer cases and 101 age/region-matched healthy controls were genotyped for rs3916840, rs1799793, and rs238416 in ERCC2 by polymerase chain reaction-restriction fragment length polymorphism. Results: The rs238416 heterozygous GA genotype combined with the rs238416 genotypes (GA + AA) showed a significant association with breast cancer susceptibility (corrected p < 0.01, odds ratio [OR] = 0.29, 95% confidence interval [CI] = 0.15-0.54; corrected p < 0.01, OR = 0.31, 95% CI = 0.17-0.56, respectively). The rs238416 GA genotype carriers had a decreased risk of breast cancer. However, we observed no significant association between the rs3916840 and rs1799793 polymorphisms in ERCC2 and breast cancer risk. Moreover, haplotype analysis showed that the ACG haplotype was associated with a significantly decreased risk of breast cancer, whereas the GCG haplotype was associated with a significantly increased risk of breast cancer (corrected p = 0.004 and p = 0.002, respectively). Multifactor dimensionality reduction analysis demonstrated that the interactions between rs3916840 and rs238416 were significantly synergistic. Conclusion: To the best of our knowledge, this study is the first to demonstrate that the rs238416 heterozygous genotype likely has a higher DNA repair capacity and, thus, can be protective against breast cancer in Chinese Han women.

Inspired by the superior fixed and traction characteristics of ostrich foot toenails, we devised, optimized and manufactured the single structure and group arrangement of a new-style bionic spike for sprint shoes to improve athletic performance. The tractive performance of the bionic spike was tested by finite element analysis and experimental verification. The optimized single structure of the bionic spike had a top slope angle of 13° and the radius of the medial groove of 7.3 mm. Compared with the conventional conic spike, the maximal and stable extrusion resistances of the single bionic spike decreased by about 25% and 40% respectively, while the maximal and stable horizontal thrusts increased by about 16% and 10%, respectively. In addition, the arrangement of the bionic spikes was also optimized. Compared with the conventional spike group, the maximal and stable extrusion resistances of the bionic spike group decreased by 11.0% and 6.2%, respectively, while the maximal and stable horizontal thrusts increased by 20.0% and 16.0%, respectively. The current results may provide useful mechanical information that can help develop a better design of athletic shoes with the potential for advanced performance.