Different configurations for riser systems have been emerged as suitable technological and economical solutions for offshore petroleum fields in ultra deep water. The study and development of methodologies for riser project considering the uncertainties involved in the manufacture process of offshore risers and effects of meteocean conditions, such as waves, current and platform motions for the fatigue failure is fundamental to increase the reliability of riser structure design. The present work presents a procedure to evaluate the probability of fatigue failure in offshore Steel Catenary Risers (SCR) identifying the influence of the main parameters in the failure process due to fatigue. Meteocean conditions and uncertainties due to accumulated fatigue damage given by Miner-Palmgren’s rule are here considered. The probabilistic methodology is taken into account, and the analytical approach based on the First Order Reliability Method (FORM) is applied considering two practical cases. In the first case, calculations are performed to compare with the results from the literature, and the second one calculation is carried out considering a typical Brazilian offshore field operation. In the calculations, results for the probability of failure, as well as, the riser service life are observed in four different locations along the SCR length. Finally, conclusions are shown to the probability of failure due to fatigue such as influence of each parameter in the process.