Atopic dermatitis and abnormalities in tooth development (including hypomineralization, hypodontia and microdontia) have been observed to co-occur in some patients. A common pathogenesis pathway that involves genes and protein interactions has been hypothesized. This review aims to first provide a description of the key gene mutations and signaling pathways associated with atopic dermatitis and tooth agenesis (i.e., the absence of teeth due to developmental failure) and identify the possible association between the two diseases. Second, utilizing a list of genes most commonly associated with the two diseases, we conducted a protein–protein network interaction analysis using the STRING database and identified a novel association between the Wnt/β-catenin signaling pathway (major pathway responsible for TA) and desmosomal proteins (component of skin barrier that affect the pathogenesis of AD). Further investigation into the mechanisms that may drive their co-occurrence and underlie the development of the two diseases is warranted.

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Background Periodontitis may result in displacement, overeruption and the tilting of teeth, which can lead to occlusal prematurities and accelerate the loss of periodontal structures. Orthodontic treatment is needed to correct displaced tooth positions, but inappropriate force and tooth movement can lead to further loss of supporting tissues. Aim To describe the treatment of a deep overbite in a 32-year-old male with a history of periodontitis, gingival recession and missing premolars. Methods After evaluation, fixed appliances applying light forces were chosen as the appropriate treatment approach. A segmental arch and a utility arch technique were applied. Periodontal therapy was conducted before and throughout orthodontic care. Results After 28 months of treatment, a normal overbite and overjet were restored. A displaced premolar was repositioned. Space needed for the prosthetic replacement of the missing teeth was obtained and dental implants were planned after orthodontic treatment. The height of the alveolar bone increased in some areas. After 18 months of retention, the attachment level of the upper left incisor increased approximately 1 mm. Conclusion For patients with a compromised periodontium, adequate management of the tissues is the basis of orthodontic care. Appropriate orthodontic treatment may be beneficial to periodontal health in the long term.