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Antidepressants can also be useful for non-classical indications such as bereavement, burn out and pain, if these conditions lead into a depressive episode or if additional effects like modulation of pain are of therapeutic benefit. Due to the range of side-effects and potential interactions, present medical condition, medication and the clinical appearance of the depressive episode have to be taken into account for the choice of the specific antidepressant. Patients need to be thoroughly informed and accompanied to build and sustain compliance. Patient's sceptical attitude towards antidepressants must be taken seriously and the risk of treatment needs to be considered.

Osteoporotic fractures most frequently first occur in the axial skeleton, especially in the vertebral bodies of the thoracolumbar transition. Beside pain, these fractures cause increasing kyphosis leading to changes in statics and a shift of the bodies' center of gravity. This results in physiological, functional as well as neurological consequences that cannot be managed by means of a conservative therapy. The purpose of this article is to provide a brief overview on diagnostics and therapy of such fractures. Furthermore, fractures of the pubic rami need to be mentioned. They pose another frequent location for osteoporotic fractures and are also associated with a high rate of morbidity and mortality.

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