The existing piano curriculum education system in colleges has been very backward. With the rapid economic development, it is also necessary to add new teaching technical means to meet the teaching needs of the new era and study the application of open teaching mode in the piano curriculum in colleges. This paper examines the current state of piano instruction in colleges and puts forward some problems, such as the serious lag of teaching mode, the backwardness of curriculum design education, and the failure of evaluation mechanism to keep pace with the times. The design is based on the open teaching mode, designs the piano course in colleges, establishes the open teaching mode, designs the open and inclusive teaching content, improves the piano teaching evaluation mechanism, and obtains a new teaching method of piano course in colleges. In the case analysis, the test results of this teaching mode and traditional teaching mode are compared. The results of the pretest and posttest show that the open teaching mode can greatly improve the teaching performance of piano courses and can be applied to practical teaching.